:root {
  --ink: #18303f;
  --muted: #657483;
  --line: #dbe4ea;
  --panel: #ffffff;
  --soft: #f4f8fb;
  --accent: #0f766e;
  --accent-dark: #115e59;
  --danger: #b42318;
  --ok: #067647;
  --shadow: 0 10px 24px rgba(24, 48, 63, 0.08);
}

* {
  box-sizing: border-box;
}

body {
  margin: 0;
  color: var(--ink);
  background: #f7fafc;
  font-family: Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  line-height: 1.5;
}

a {
  color: var(--accent-dark);
}

button,
input,
select {
  font: inherit;
}

button {
  border: 0;
  border-radius: 6px;
  color: #fff;
  background: var(--accent);
  padding: 0.7rem 0.95rem;
  cursor: pointer;
}

button:hover {
  background: var(--accent-dark);
}

button.secondary {
  color: var(--ink);
  background: #e8eef2;
}

input,
select {
  width: 100%;
  border: 1px solid var(--line);
  border-radius: 6px;
  background: #fff;
  color: var(--ink);
  padding: 0.65rem 0.75rem;
}

.site-header {
  position: sticky;
  top: 0;
  z-index: 20;
  background: rgba(255, 255, 255, 0.96);
  border-bottom: 1px solid var(--line);
  backdrop-filter: blur(8px);
}

.header-inner {
  max-width: 1180px;
  margin: 0 auto;
  padding: 0.7rem 1.25rem;
  display: flex;
  align-items: center;
  gap: 1.2rem;
}

.brand {
  font-weight: 800;
  font-size: 1.2rem;
  color: var(--ink);
  text-decoration: none;
}

.tabs {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  gap: 0.25rem;
  margin-left: auto;
}

.tabs a {
  color: var(--muted);
  text-decoration: none;
  border-radius: 999px;
  padding: 0.45rem 0.7rem;
  font-size: 0.95rem;
}

.tabs a.active,
.tabs a:hover {
  color: var(--accent-dark);
  background: #e7f5f2;
}

.nav-toggle {
  display: none;
  margin-left: auto;
  color: var(--ink);
  background: #edf3f6;
}

main {
  max-width: 1180px;
  margin: 0 auto;
  padding: 1.2rem;
}

.welcome {
  display: none;
  grid-template-columns: minmax(0, 1fr) 320px;
  gap: 1.2rem;
  align-items: stretch;
  margin: 1rem 0 1.4rem;
  padding: 2rem;
  background: linear-gradient(135deg, #eaf7f4, #f7fbfd);
  border: 1px solid #d7ece7;
  border-radius: 8px;
}

.welcome.active {
  display: grid;
}

.welcome h1 {
  margin: 0 0 0.7rem;
  font-size: clamp(2rem, 4vw, 3.6rem);
  line-height: 1.05;
  letter-spacing: 0;
}

.welcome p {
  max-width: 780px;
  margin: 0 0 0.75rem;
  color: #385161;
  font-size: 1.04rem;
}

.eyebrow {
  color: var(--accent-dark) !important;
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  font-size: 0.78rem !important;
}

.stat-line {
  font-weight: 700;
  color: var(--ink) !important;
}

.quick-links {
  display: grid;
  align-content: center;
  gap: 0.65rem;
}

.quick-links a {
  display: block;
  padding: 0.85rem 1rem;
  border-radius: 6px;
  background: var(--panel);
  box-shadow: var(--shadow);
  text-decoration: none;
  font-weight: 700;
}

.welcome-figures {
  grid-column: 1 / -1;
  max-width: 700px;
  width: 100%;
  min-height: 110px;
  display: grid;
  grid-template-columns: repeat(6, minmax(0, 1fr));
  gap: clamp(0.5rem, 2vw, 1.5rem);
  align-items: end;
  justify-items: center;
  margin: 1.5rem auto 0;
}

.organism-icon {
  display: block;
  width: 100%;
  object-fit: contain;
  object-position: center bottom;
}

.organism-icon-human {
  height: 110px;
}

.organism-icon-macaca,
.organism-icon-mouse,
.organism-icon-pig,
.organism-icon-drosophila {
  height: 74px;
}

.organism-icon-rat {
  height: 87px;
}

.tab-panel {
  display: none;
  background: var(--panel);
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 1.25rem;
  box-shadow: var(--shadow);
}

.tab-panel.active {
  display: block;
}

.section-heading {
  display: flex;
  justify-content: space-between;
  gap: 1rem;
  align-items: start;
  margin-bottom: 1rem;
}

.section-heading h2,
.prose h2 {
  margin: 0;
  font-size: 1.7rem;
}

.section-heading p {
  margin: 0.25rem 0 0;
  color: var(--muted);
}

.status {
  display: inline-flex;
  align-items: center;
  min-height: 1.9rem;
  padding: 0.25rem 0.6rem;
  border-radius: 8px;
  color: var(--accent-dark);
  background: #e7f5f2;
  font-size: 0.85rem;
  white-space: nowrap;
}

#de-status {
  min-width: 10rem;
  padding: 0.65rem 0.85rem;
  line-height: 1.5;
  white-space: pre-line;
  flex-shrink: 0;
  justify-content: center;
  text-align: center;
}

.muted {
  color: var(--muted);
}

.notice {
  margin: 0 0 1rem;
  padding: 0.75rem 0.9rem;
  border-radius: 6px;
  background: #fff7ed;
  color: #7c2d12;
}

.control-grid {
  display: grid;
  grid-template-columns: repeat(4, minmax(0, 1fr));
  gap: 0.8rem;
  align-items: end;
  margin-bottom: 1rem;
}

.gene-controls {
  grid-template-columns: 1fr 2fr 1.2fr auto;
}

label {
  display: grid;
  gap: 0.35rem;
  color: #405363;
  font-weight: 700;
  font-size: 0.92rem;
}

.table-toolbar {
  display: flex;
  align-items: center;
  gap: 0.8rem;
  margin: 0.5rem 0 0.8rem;
}

.table-toolbar input {
  max-width: 420px;
}

.table-wrap {
  overflow: auto;
  border: 1px solid var(--line);
  border-radius: 8px;
}

.table-wrap.tall {
  max-height: 560px;
}

table {
  width: 100%;
  border-collapse: collapse;
  min-width: 880px;
}

th,
td {
  padding: 0.65rem 0.75rem;
  border-bottom: 1px solid var(--line);
  text-align: left;
  vertical-align: top;
}

th {
  position: sticky;
  top: 0;
  z-index: 1;
  background: var(--soft);
  color: #34495a;
  font-size: 0.88rem;
}

.sort-button {
  padding: 0;
  border-radius: 0;
  color: inherit;
  background: transparent;
  font-weight: inherit;
}

.sort-button:hover {
  color: var(--accent-dark);
  background: transparent;
  text-decoration: underline;
}

th[aria-sort="ascending"] .sort-indicator::after {
  content: " \25B2";
}

th[aria-sort="descending"] .sort-indicator::after {
  content: " \25BC";
}

tbody tr:hover {
  background: #f8fbfc;
}

.pill {
  display: inline-flex;
  align-items: center;
  border-radius: 999px;
  padding: 0.15rem 0.5rem;
  background: #edf3f6;
  font-size: 0.82rem;
  font-weight: 700;
}

.up {
  color: var(--danger);
}

.down {
  color: #175cd3;
}

.ns {
  color: var(--muted);
}

.plot-shell {
  min-height: 430px;
  border: 1px solid var(--line);
  border-radius: 8px;
  background: #fbfdfe;
  color: var(--muted);
  padding: 1rem;
}

.plot-shell.is-empty {
  display: grid;
  place-items: center;
}

.plot-shell.is-empty #expression-plot,
.plot-shell.is-empty #forest-plot {
  display: none;
}

.plot-shell:not(.is-empty) .plot-placeholder {
  display: none;
}

#expression-plot,
#forest-plot {
  width: 100%;
  min-height: 430px;
}

#meta {
  width: min(1400px, calc(100vw - 2.4rem));
  margin-left: 50%;
  transform: translateX(-50%);
}

.downloads-grid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 1rem;
}

.download-all-note {
  margin-bottom: 1rem;
  padding: 0.9rem 1rem;
  border: 1px solid #d7ece7;
  border-radius: 8px;
  background: #eaf7f4;
}

.download-all-note p {
  margin: 0.3rem 0 0.55rem;
}

.download-all-note code {
  display: block;
  overflow-wrap: break-word;
  white-space: normal;
}

.download-group {
  border: 1px solid var(--line);
  border-radius: 8px;
  padding: 1rem;
  background: #fbfdfe;
}

.download-group-wide {
  grid-column: 1 / -1;
}

.download-group h3 {
  margin: 0 0 0.65rem;
}

.download-group h4 {
  margin: 0.8rem 0 0.35rem;
}

.download-group ul {
  margin: 0;
  padding-left: 1.1rem;
}

.download-group li {
  margin: 0.25rem 0;
}

.download-group a,
.download-actions,
.contrast-name {
  min-width: 0;
  overflow-wrap: break-word;
}

.download-details {
  border-top: 1px solid var(--line);
  padding: 0.45rem 0;
}

.download-details summary {
  cursor: pointer;
  color: var(--accent-dark);
  font-weight: 700;
}

.download-study {
  padding-left: 1rem;
}

.contrast-downloads {
  list-style: none;
  padding-left: 0 !important;
}

.contrast-downloads li {
  display: grid;
  grid-template-columns: minmax(0, 1fr) auto;
  gap: 0.6rem 1rem;
  align-items: baseline;
  padding: 0.35rem 0;
  border-bottom: 1px solid var(--line);
}

.download-actions {
  display: flex;
  flex-wrap: wrap;
  gap: 0.35rem 0.75rem;
}

#methods {
  max-width: 780px;
  margin-right: auto;
  margin-left: auto;
}

#methods p {
  max-width: 720px;
}

footer {
  max-width: 1180px;
  margin: 1rem auto 2rem;
  padding: 0 1.2rem;
  color: var(--muted);
  display: flex;
  justify-content: space-between;
}

footer.methods-aligned {
  max-width: 780px;
}

@media (max-width: 860px) {
  #meta {
    width: 100%;
    margin-left: 0;
    transform: none;
  }

  .header-inner {
    flex-wrap: wrap;
  }

  .nav-toggle {
    display: inline-flex;
  }

  .tabs {
    display: none;
    width: 100%;
    margin-left: 0;
  }

  .tabs.open {
    display: flex;
  }

  .welcome,
  .downloads-grid {
    grid-template-columns: 1fr;
  }

  .contrast-downloads li {
    grid-template-columns: 1fr;
  }

  .control-grid,
  .gene-controls {
    grid-template-columns: 1fr;
  }

  .section-heading,
  .table-toolbar {
    align-items: stretch;
    flex-direction: column;
  }
}